BJP national president Shah and Union Finance Minister Jaitley are likely to visit the hospital in the afternoon, they added.
Sources at the Chennai airport said the two leaders were likely to arrive from Delhi, proceed to Apollo hospital and return the same day.
Jayalalithaa (68) was admitted to the hospital on September 22 after she complained of fever and dehydration.
A stream of high-profile visitors, including Governors of Tamil Nadu and Kerala Chennamaneni Vidyasagar Rao and P Sathasivam, Union minister M Venkaiah Naidu, Congress vice-president Rahul Gandhi and Chief Ministers of Kerala and Puducherry Pinarayi Vijayan and V Narayanasamy have visited the hospital.
PTI